|Date: Tuesday, April 01, 2014
Title: Central Problems in Biological Clocks: Identifying Structures and Functions of Biochemical Interaction Networks
Abstract: Cells generate various biological rhythms that control important aspects of cell physiology including circadian (daily) events, cell division, and DNA damage repair. Since these cellular rhythms can determine the fitness or fate of organisms, how cells generate and control rhythms has become a central problem in biology. While many biochemical interactions underlying biological clocks have been found, identifying entire biochemical interaction network is still far from complete due to the limit of experimental techniques. On the other hand, output of the networks, timecourses of genes and proteins can be easily acquired with advances in technology. I will describe how to use these timecourse data to reveal biochemical network structure by using a fixed-point criteria. Moreover, I will discuss how the structures of biochemical networks play role in maintaining rhythms and regulating periods of two important biological rhythms: circadian rhythms and p53 rhythms.
Speaker: Jae Kyoung Kim
Institution: Mathematical Biosciences Institute, The Ohio State University