|Date: Friday, November 13, 2015
Location: 1084 East Hall (4:10 PM to 5:00 PM)
Title: HPV as the Etiological Agent of Oral Cancer
Abstract: The human papillomavirus (HPV) infects multiple sites in the human epithelium (genitals, oral cavity, anal canal) and is responsible for over 90% of anogenital cancer and an increasing percentage of cancer of the oral cavity, primarily in the oropharynx. We leverage age-period-cohort (APC) epidemiological models combined with multistage clonal expansion (MSCE) models (stochastic models of cancer biology) to consider temporal trends and demographic differences in incidence of oral squamous cell carcinomas in the Surveillance, Epidemiology, and End Results (SEER) cancer registry for three groups of subsites: presumed HPV-related, presumed HPV-unrelated, and oral tongue. This method allows us to distinguish between period and birth cohort temporal effects as well as make inferences about the underlying cancer biology.
Speaker: Andrew Brouwer
Institution: University of Michigan
Event Organizer: Derek Wood and Jeremy Hoskins